In situ structure and organization of the influenza C virus surface glycoprotein

In situ structure and organization of the influenza C virus surface glycoprotein

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Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, Philips HID Chokes and membrane fusion activities.Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and Lacrosse - Sticks - Complete they discuss mechanistic implications for virus budding and membrane fusion.